Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

Kaohsiung Medical University

Status: Unknown

Conditions: Chronic Liver Disease; Hepatocellular Carcinoma

Treatments: Other: TNF-alpha and HBV genotypes; Genetic: TNF-alpha and HBV genotype

Study type: Interventional

Funder types: Other

Identifiers

NCT00629668

KMUH-IRB-940189

Details and patient eligibility

About

The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• HBV-positive patients

Exclusion criteria

• HBV-negative patients

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)