Genetic Polymorphisms & The Risk for Sepsis After Trauma

University of Washington

Status: Completed

Conditions: Trauma

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT02021552

44109-A

Details and patient eligibility

About

The specific aim of this is to establish a cohort of severely injured patients admitted to our trauma center. Investigators will collect DNA, utilizing discarded blood samples, from 3000 injury victims in an effort to identify perhaps 50 - 100 single-nucleotide polymorphisms (SNP) (out of 1000s) that can be used, when taken together, to identify patients at highest risk for developing complicated sepsis and death.

Full description

The specific aim of this is to establish a cohort of severely injured patients admitted to our trauma center. Investigators will collect DNA, utilizing discarded blood samples, from 3000 injury victims in an effort to identify perhaps 50 - 100 single-nucleotide polymorphisms (SNP) (out of 1000s) that can be used, when taken together, to identify patients at highest risk for developing complicated sepsis and death

Enrollment: 357 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Admitted to the Intensive Care Unit (ICU) at Harborview Medical Center after suffering a traumatic injury

• ability to obtain a 5 ml blood sample
• Expected to be in the ICU for more than 24 hours

Exclusion criteria

• We will exclude subjects with chronic medical conditions for the reasons stated above as well as vulnerable populations (children, pregnant females, and prisoners)

Trial design

357 participants in 1 patient group

trauma patients

Description:

trauma patients 18 years or older requiring treatment in the ICU \>24 hours. All subjects will undergo blood sampling.

Treatment:

Other: blood sampling