Genetic Predictors of Renal Dysfunction Following Heart Transplantation

University of Colorado Denver (CU Denver)

Status: Active, not recruiting

Conditions: Chronic Renal Insufficiency; Heart Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT01686191

TL1TR002533 (U.S. NIH Grant/Contract)

UL1TR002535 (U.S. NIH Grant/Contract)

12GRNT12040211 (Other Grant/Funding Number)

12-0869

Details and patient eligibility

About

Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a person's genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• cardiac-only transplant
• 18 years of age or older at the time of cardiac transplant
• 1 year or more post-cardiac transplant
• treatment with cyclosporine or tacrolimus following transplant

Exclusion criteria

• combined organ transplant
• decisionally impaired
• unable to read or speak English
• unable or unwilling to provide written informed consent

Trial design

300 participants in 1 patient group

Cardiac transplant recipients