Genetic Predisposition for Chronic Non-specific Low Back Pain (Backgene)

Balgrist University Hospital

Status: Completed

Conditions: Low Back Pain

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02955407

2016-00647

Details and patient eligibility

About

Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).

Full description

The following genes will be investigated:

• Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).
• Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772

The goals of this study are to investigate whether these genotypes correlate with 1) endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for LBP as assessed by a LBP-classification tool.

Enrollment: 100 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65

Exclusion criteria

• Spinal surgery
• Spinal fracture
• Inflammation
• Tumour
• Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)

Trial design

100 participants in 2 patient groups

Low back pain patients

Description:

Low back pain since more than 3 months Age: 18-65 Caucasian race

Treatment:

Other: no intervention

Controls without low back pain

Description:

no low back ain Age: 18-65 Caucasian race

Treatment:

Other: no intervention