Genetic Studies in Familial Dementia

University of Miami

Status: Completed

Conditions: Dementia of Alzheimer Type; Mild Cognitive Impairment; Alzheimer Disease, Late Onset; Dementia; Alzheimer Disease, Early Onset

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04680013

RF1AG054074 (U.S. NIH Grant/Contract)

20070307

RF1AG054080 (U.S. NIH Grant/Contract)

U01AG052410 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to identify genetic factors that contribute to or cause dementia (loss of memory) and related disorders across all ages and ethnic groups. This includes a number of neurological diseases such as early and late-onset Alzheimer disease, mild cognitive impairment, and other dementias.

Enrollment: 4,884 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 18 years and older
2. Patients diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion criteria

1. Individuals with competing diagnosis such as: Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, Multiple system atrophy, Corticobasal degeneration, Progressive Supranuclear Palsy, Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc. (unless family members of a dementia affected individual).

Trial design

4,884 participants in 3 patient groups

Cognitive Control

Description:

Participants in this group are cognitively intact.

Mild Cognitive Impairment

Description:

Participants in this group have mild cognitive impairment.

Dementia Group

Description:

Participants in this group have dementia.