Genetic Studies of Early-onset Dementia

Columbia University

Status: Enrolling

Conditions: Dementia, Early Onset

Treatments: Other: Medical questionnaire; Other: Neurocognitive testing; Genetic: Blood draw

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04906863

AAAQ9793

1R01AG064614 (U.S. NIH Grant/Contract)

5U24AG056270-07 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

Full description

The study population includes individuals affected by Alzheimer's Disease, mild cognitive impairment, other dementias, cognitively healthy individuals without memory problems, or their family members.

Ascertainment is across both males and females, and all race and ethnic groups.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years and older
• Individuals diagnosed with dementia, their family members and unrelated healthy controls without dementia.

Exclusion criteria

-Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual

Trial design

1,000 participants in 3 patient groups

Mild Cognitive Impairment

Description:

Individuals with mild cognitive impairment that began before age 70

Treatment:

Genetic: Blood draw

Other: Neurocognitive testing

Other: Medical questionnaire

Dementia/Alzheimer's Disease

Description:

Individuals with Alzheimer's Disease or other dementia that began before age 70

Treatment:

Genetic: Blood draw

Other: Neurocognitive testing

Other: Medical questionnaire

Cognitively Healthy

Description:

Cognitively healthy individuals over the age of 30 years

Treatment:

Genetic: Blood draw

Other: Neurocognitive testing

Other: Medical questionnaire