Genetic Study in Patients With Stage II or Stage III Colon Cancer

Alliance for Clinical Trials in Oncology

Status: Completed

Conditions: Colorectal Cancer

Treatments: Genetic: gene mapping; Genetic: DNA stability analysis

Study type: Observational

Funder types: Other; NETWORK; NIH

Identifiers

NCT00003833

CDR0000066990 (Registry Identifier)

NCCTG-984654

CAN-NCIC-CO9PATH

Details and patient eligibility

About

RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer.

PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.

Full description

OBJECTIVES:

• Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer.
• Determine if patient prognosis is dependent on the region of 8p AI.
• Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p.
• Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI.

OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.

Enrollment: 598 patients

Sex: All

Ages: Under 69 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of resectable stage II or III adenocarcinoma of the colon
• Participated in NCCTG-914653
• DNA extracted from both normal and tumor tissue

PATIENT CHARACTERISTICS:

Age

• Under 70

Trial design

598 participants in 1 patient group

Normal and tumor tissue pairs

Description:

Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.

Treatment:

Genetic: gene mapping

Genetic: DNA stability analysis