Genetic Susceptibility Factors for Candidemia.

University Hospital, Lille

Status: Completed

Conditions: Candidemia; Genetic Predisposition to Disease; Invasive Candidiasis

Treatments: Genetic: Analysis of genetic polymorphisms

Study type: Observational

Funder types: Other

Identifiers

NCT02841501

2011_63

2012-A01344-39 (Other Identifier)

Details and patient eligibility

About

This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.

Enrollment: 453 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient older than 18 years.
• Informed consent.
• Positive blood culture with isolation of Candida sp.

Exclusion criteria

• No informed consent.
• Patient younger than 18.
• No insurance coverage.

Trial design

453 participants in 2 patient groups

Candidemia patients

Description:

These patients are included in the study after the reception of a positive blood culture for Candida sp.

Treatment:

Genetic: Analysis of genetic polymorphisms

Control patients

Description:

These patients are matched on case patients on the following criteria: * Age+/-5 years * length of hospitalisation * type of ward * type of surgery for surgical patients * IGS2 for intensive care patients

Treatment:

Genetic: Analysis of genetic polymorphisms