Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial

Mayo Clinic

Status

Terminated

Conditions

Stage IVA Colon Cancer AJCC v8

Stage IV Colon Cancer AJCC v8

Stage IIIC Colon Cancer AJCC v8

Stage III Rectal Cancer AJCC v8

Stage IVB Rectal Cancer AJCC v8

Stage IIIC Rectal Cancer AJCC v8

Metastatic Rectal Adenocarcinoma

Metastatic Colon Adenocarcinoma

Stage IIIB Colon Cancer AJCC v8

Stage IIIA Rectal Cancer AJCC v8

Stage IVA Rectal Cancer AJCC v8

Stage IVC Colon Cancer AJCC v8

Stage IV Rectal Cancer AJCC v8

Stage IVC Rectal Cancer AJCC v8

Unresectable Rectal Adenocarcinoma

Stage III Colon Cancer AJCC v8

Stage IIIB Rectal Cancer AJCC v8

Stage IVB Colon Cancer AJCC v8

Unresectable Colon Adenocarcinoma

Stage IIIA Colon Cancer AJCC v8

Treatments

Other: Genetic Testing

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT03765736

P30CA015083 (U.S. NIH Grant/Contract)

NCI-2018-02862 (Registry Identifier)

ACCRU-GI-1611 (Other Identifier)

Details and patient eligibility

About

This trial screens patients with colon or rectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) for genetic mutations for recommendation to a molecularly assigned therapy. Identifying gene mutations may help patients enroll onto target companion trials that target these mutations.

Full description

PRIMARY OBJECTIVES:

I. To perform blood-based genomic profiling on patients with treatment refractory metastatic colorectal cancer (CRC) to facilitate accrual to molecularly assigned therapies.

II. To facilitate clinically annotated genomic analyses.

OUTLINE:

Patients submit blood samples for genetic testing.

Enrollment

199 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histological confirmation of adenocarcinoma of the colon or rectum that is metastatic and/ or unresectable
Progression, intolerance, or contraindication to a fluoropyrimidine (e.g., 5- fluorouracil or capecitabine), oxaliplatin, irinotecan, an anti-VEGF monoclonal antibody (bevacizumab, ziv-aflibercept, or ramucirumab), and an anti-PD-1 monoclonal antibody (nivolumab or pembrolizumab) if tumor has deficient mismatch repair proteins (dMMR) or is microsatellite instability-high (MSI-H)
For patients with KRAS and NRAS wild-type tumors, progression, intolerance, or contraindication to an anti-EGFR monoclonal antibody (cetuximab or panitumumab)
- Note: If tissue is known to be positive for HER2 expression (IHC 3+) or the tumor has ERBB2 (HER2) amplification detected by a Clinical Laboratory Improvement Act (CLIA)-certified assay, prior treatment with anti-EGFR therapy is not required
At least one site of disease that is measurable by Response Evaluation Criteria in Solid Tumors (RECIST) criteria (version 1.1) that has not been previously irradiated; if the patient has had previous radiation to the target lesion(s), there must be evidence of progression since the radiation
Life expectancy >= 3 months per estimation of investigator
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2
Capable of understanding and complying with the protocol requirements and has signed the informed consent document
Satisfy at least one of the following two conditions:
- Willing and able to provide blood sample for screening purposes
- Guardant 360 testing completed =< 60 days prior to registration

Exclusion criteria

Evidence within the last 3 years of another malignancy which required systemic treatment. EXCEPTIONS: Non-melanotic skin cancer, carcinoma-in-situ of the cervix, or localized prostate cancer with a current PSA of < 1.0mg/dL on 2 successive evaluations, at least 90 days apart, with the most recent evaluation no more than 4 weeks prior to registration
Unable or unwilling to abide by the study protocol or cooperate fully with the investigator or designee
History of solid organ transplantation
Pregnant or planning to become pregnant within the next 12 months