Genetic Variants and Non-genetic Variables and Postoperative Nausea and Vomiting

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Analgesia; Surgical Procedure, Operative; Anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT03490175

041/09b PONV

Details and patient eligibility

About

Prospective observational study to analyse the association of non-genetic variables as well as genetic variants of candidate genes with the incidence of postoperative nausea and vomiting (PONV).

Full description

Background

Surgery and anesthesia are related to unwanted adverse events, side effects and postoperative discomfort. Postoperative nausea and vomiting are frequent and the question arises which patient is at specific risk for these sequelae. Some predisposing factors for PONV are well described, e.g. female sex, non-smoking status and postoperative opioids. Some drugs used for anesthesia as well as surgery related variables might induce PONV.

In this prospective association study patient related variables, surgical and anesthesia related variables as well as genetic variants of several candidate genes will be investigated in a well-described patient cohort presenting for scheduled surgery.

Objective

The aim of this study is to investigate a possible association of non-genetic variables and genetic variants with PONV.

Methods

Prospective association study performed in patients recovering form elective surgery and anesthesia.

Enrollment: 2,778 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 18 years and older
• Written informed consent
• Elective surgery

Exclusion Criteria

• No written informed consent
• Cognitive impairment

Trial design

2,778 participants in 1 patient group

All patients

Description:

Patients undergoing general anesthesia for elective surgery