Genetic Variants and Postoperative Pain

Insel Gruppe AG, University Hospital Bern

Status: Enrolling

Conditions: Postoperative Pain; Analgesia; Surgical Procedure, Operative

Study type: Observational

Funder types: Other

Identifiers

NCT03489499

041/09c Schmerz

Details and patient eligibility

About

Prospective observational study to analyse patients' pain related outcome after surgery and ist association to genetic variants and non-genetic variables.

Full description

Background

Severe acute pain as well as long-lasting pain after surgery and pain-related interference of daily activities are frequent. Some risk factors for severe pain after surgery in adults have been described, e.g. younger age and pre-existing chronic pain. The question arises whether a specific genetic background is related to an unfavorable pain outcome.

Objective

The aim of this study is to investigate clinical and genetic variables and their possible association to severe acute postoperative pain, higher analgesic consumption and the development of chronic postsurgical pain.

Methods

Prospective observational study investigating clinical, patient related, surgery related and anesthesia related variables as well as genetic variants and their possible association to patients' pain related outcome after surgery.

Enrollment: 5,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 18 years and older
• Written informed consent
• Elective surgery
• Patients' ability to understand the purpose of the study

Exclusion Criteria

• No informed consent
• Cognitive impairment

Trial design

5,000 participants in 1 patient group

All patients

Description:

Patients undergoing elective surgery with anesthesia