Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response

Institut Universitari Dexeus

Status: Completed

Conditions: Fertility Disorders

Treatments: Other: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT03007043

2016.Polymorphisms_COS

Details and patient eligibility

About

To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation

Enrollment: 364 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age between 18-38 years old
2. BMI 18-28
3. Antral follicle count (AFC) > 9 or Anti-mullerian hormone (AMH) >1.1 ng/ml
4. 1st or 2nd ovarian stimulation cycle for IVF/ICSI
5. Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol

Exclusion criteria

1. Antral follicle count (AFC) <9 and AMH<1.1 ng/ml
2. PCOS patients according to the Rotterdam criteria
3. Patients undergoing in vitro maturation (IVM)
4. Untreated endocrine abnormalities

Trial design

364 participants in 2 patient groups

Normal responders

Description:

Normal response following IVF

Treatment:

Other: blood sample

Suboptimal responders

Description:

Suboptimal response following IVF

Treatment:

Other: blood sample