Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease (NAFLDDMCKD)

University of Pecs

Status: Unknown

Conditions: Chronic Kidney Disease; Diabetes Mellitus; Non-alcoholic Fatty Liver Disease

Treatments: Other: non-interventional study

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02947568

Pecs_NAFLD_01

Details and patient eligibility

About

The present study investigates relationship between non-alcoholic fatty liver disease and its risk factors, such as genetic background and diseases, such as chronic kidney disease and diabetes mellitus.

Full description

Non-alcoholic fatty liver disease (NAFLD) is a multisystemic disease, also affecting extrahepatic organs (1,2,6). According to former data, not only the prevalence of chronic hepatic disease, chronic cardiovascular diseases, but also the prevalence of chronic kidney disease (CKD) is higher in NAFLD (4,7). A strong association has been shown between diabetes mellitus (DM) and NAFLD as well (3,5,10).

Many genetical factors have been studied in the background of NAFLD. Many studies have proved the effect of patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) (8,9). Effect of numerous genetical polymorphisms has been suggested behind oxidative stress responsible for NAFLD (8).

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CKD (renal replacement therapy non excluded)
• DM
• CKD+DM

Exclusion criteria

• alcohol abuse

Trial design

600 participants in 3 patient groups

CKD

Description:

chronic kidney disease

Treatment:

Other: non-interventional study

DM

Description:

diabetes mellitus

Treatment:

Other: non-interventional study

CKD+DM

Description:

chronic kidney disease + diabetes mellitus

Treatment:

Other: non-interventional study