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Genetics of Alpha Thalassemia in Israeli Ethnic Groups

D

Deborah Rund

Status

Completed

Conditions

Alpha Thalassemia

Study type

Observational

Funder types

Other

Identifiers

NCT00159029
152910-HMO-CTIL

Details and patient eligibility

About

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Full description

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Enrollment

100 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • diagnosis of deletional alpha thalassemia

Exclusion criteria

  • under age 18

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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