Genetics Study of Wet Age-Related Macular Degeneration (AMD) Non-Responders to Vascular Endothelial Growth Factor (VEGF) Therapy

West Coast Retina Medical Group, Inc.

Status: Unknown

Conditions: Wet AMD

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01310686

FVF4990s

Details and patient eligibility

About

To obtain a genotypic analysis of patients with chronic exudative age-related macular degeneration noted to have subretinal or intraretinal edema despite continuous monthly Anti-VEGF therapy.

Enrollment: 40 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ability to provide written informed consent for participation in this study
• Subjects diagnoses of neovascular AMD who are on a monthly anti-VEGF regimen (have had >10 or more ranibizumab and/or bevacizumab injections within the last year) and who still have intra-retinal or subretinal fluid as confirmed by the Investigator

Exclusion criteria

• Subjects with a Pigment Epithelial Detachment Exclusively
• Subjects with Serous Pigment Epithelial Detachments
• Subjects with history of the following:

idiopathic polypoidal choroidal vasculopathy

• pathologic degenerative myopia
• central serous chorioretinopathy
• familial drusen
• adult onset foveal pattern dystrophy

Trial design

40 participants in 1 patient group

Wet AMD Non-Responders to Anti-VEGF