Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis

Ain Shams University

Status: Not yet enrolling

Conditions: Joint Pain

Treatments: Procedure: genicular nerve neurolysis

Study type: Interventional

Funder types: Other

Identifiers

NCT06864390

FMASU R17/2025

Details and patient eligibility

About

The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term of NRS pain score.

The participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks.

Enrollment: 114 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Grade 4 knee osteoarthritis according to Kellgren-Lawrence radiological classification.
• Failure to manage pain with conservative methods.

Exclusion criteria

• Prior knee replacement
• Patients with cardiac pacemakers or implantable cardiac defibrillators.
• Septic knee or systemic sepsis.
• Allergy to any of the drugs used in the study.
• Coagulopathy or patients on anticoagulants.
• Patients with psychiatric illness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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114 participants in 2 patient groups

genicular nerve phenol neurolysis

Experimental group

Description:

chemical neurolysis using 2 mL of 9% phenol solution prepared from crystallized phenol will be applied to each genicular nerve.

Treatment:

Procedure: genicular nerve neurolysis

genicular nerve radiofrequency ablation

Experimental group

Description:

Radiofrequency thermocoagulation will be applied to each nerve at 80 degrees for 90 seconds.

Treatment:

Procedure: genicular nerve neurolysis