Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease

Seoul National University

Status: Completed

Conditions: Mycobacterium Infections, Nontuberculous

Study type: Observational

Funder types: Other

Identifiers

NCT02832843

H-1605-111-763

Details and patient eligibility

About

The aim of this study was to elucidate genetic susceptibility of patients with nontuberculous mycobacterial lung disease using genome-wide association study.

Full description

Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms. NTM lung disease is increasing, however, genetic susceptibility of patients with the disease have not been identified. To elucidate the genetic susceptibility of NTM lung disease, the investigators perform a genome-wide association study (GWAS) including patients with NTM lung disease and healthy controls (case : control = 1 : 3). The age-, sex-matched control group will be recruited from the Korean Healthy Twin Study.

Enrollment: 2,808 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Case: Patients with NTM lung disease satisfying diagnostic criteria suggested by American Thoracic Society
• Control: Healthy subjects enrolled in the Korean Healthy Twin Study

Exclusion criteria

• Case: none
• Control: 1) Subjects who have respiratory symptoms including cough and sputum 2) Subjects who have abnormalities on chest radiography

Trial design

2,808 participants in 2 patient groups

NTM lung disease

Description:

Patients with NTM lung disease satisfying American Thoracic Society guidelines

Healthy control

Description:

The age-, sex-matched control subjects without pulmonary diseases