Genomewide Screening of Pathological Myopia

National Taiwan University logo

National Taiwan University

Status

Unknown

Conditions

Pathological Myopia

Study type

Observational

Funder types

Other

Identifiers

NCT00155753
9100205245

Details and patient eligibility

About

The purpose of this study is to evaluate the possible candidate gene of pathological myopia

Full description

High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins. Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.

Enrollment

600 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

They are unrelated Chinese subjects with high myopia ≦-6.00D. The diagnosis of myopia is determined by the refractive error. Anisometropic individuals, with a refractive error of ≦-6.00 D for one eye and ≦-6.00 D for the other eye, with at least a 2-D difference between the two eyes, are considered unaffected.

Exclusion criteria

Individuals are excluded if there is known ocular disease or insult that could predispose to myopia, such as retinopathy of prematurity or early-age media opacification, or if they had a known genetic disease associated with myopia, such as Stickler or Marfan syndrome.

Trial contacts and locations

1

Loading...

Central trial contact

Yung-Feng Shih, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems