Genomic Predictors of Papillary Microcarcinoma Disease Progression

Memorial Sloan Kettering Cancer Center (MSK)

Status: Enrolling

Conditions: Papillary Microcarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT02363595

14-277

Details and patient eligibility

About

The study is being done to answer the following question: What are the specific clinical and molecular features that will help us predict which small thyroid cancers are likely to grow and be problematic?

Therefore, the purpose of this study is to identify specific clinical and molecular characteristics that are predictive of tumor progression in small thyroid cancers.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Biopsy proven papillary thyroid cancer (or suspicious for papillary thyroid cancer) confirmed by MSKCC cytopathologist.
• Being followed with active surveillance at MSKCC
• Biopsied index nodule less than or equal to 2 cm in maximum dimension
• Thyroid and neck US performed and interpreted by a MSKCC radiologist within 6 months prior to study entry.

Exclusion criteria

• Biopsied index nodule greater than 2 cm in any dimension
• Age less than 18 yrs old

Trial design

500 participants in 1 patient group

Papillary Microcarcinoma

Description:

This clinical trial protocol describes implementation of a prospective observation protocol to standardize data collection and obtain permission to collect samples of PMC tumors in a cohort of PMC patients being followed with active surveillance. This will allow PMC tumors to be accurately classified as either stable or progressive over time and used for comprehensive molecular profiling if surgical removal is required during follow-up