Genomic Study in Non-small Cell Lung Cancer Brain Metastasis

National Cheng-Kung University

Status: Completed

Conditions: Brain Metastases; NSCLC Stage IV

Treatments: Procedure: craniectomy

Study type: Observational

Funder types: Other

Identifiers

NCT04745715

A-ER-109-437

Details and patient eligibility

About

The investigators collected the data from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course.

Full description

The investigators collected the data from from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course. The investigators use Kaplan-Meier regression to analyze the overall survival, and the difference between the groups was calculated using log rank test. Cox proportional hazards method was used to create the regression model and estimate the hazard ratios.

Enrollment: 110 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with non-small cell lung cancer who underwent craniectomy and subsequent whole brain radiotherapy and associated chemo or target therapy

Exclusion criteria

• patient who did not receive postoperative adjuvant therapy