Genotype-phenotype Correlation of SLC26A4 in CI Patients With EVA

Zhejiang University

Status: Unknown

Conditions: Enlarged Vestibular Aqueduct; Sensorineural Hearing Loss

Treatments: Procedure: Cochlear implantation

Study type: Observational

Funder types: Other

Identifiers

NCT04934605

2013-007

Details and patient eligibility

About

To explore the genotype-phenotype correlation of SLC26A4 mutations in cochlear-implanted patients with enlarged vestibular aqueduct.

Full description

Enlarged vestibular aqueduct (EVA) is one of the most common forms of inner ear malformation that cause sensorineural hearing loss (SNHL). Some patients with EVA present delayed, fluctuating, and progressive hearing loss, while the others are with congenital or sudden hearing loss. Cochlear implants (CI) have been widely used in patients with severe-profound SNHL. However, it is difficult to define the optimal timing of CI operations for patients with EVA. Mutations in SLC26A4 are known to be responsible for EVA. This study is to explore the genotype-phenotype correlation of SLC26A4 mutations in cochlear-implanted patients with EVA.

Enrollment: 60 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Bilateral severe-to-profound sensorineural hearing loss who received cochlear implantation.
2. Bilateral or unilateral enlarged vestibular aqueduct (EVA) with or without Mondini malformation (IP-II) on temporal bone computed tomography (CT) and/or magnetic resonance imaging (MRI).

Exclusion criteria

1. Hearing loss that is associated with symptoms which meet the criteria of already known syndromes.
2. With other type of inner ear malformation.