Geriatric Assessment (GA) for Elderly Patients Undergoing Allo-HSCT

Peking University

Status: Not yet enrolling

Conditions: Geriatric Assessment; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; Elderly

Treatments: Procedure: Geriatric Assessment

Study type: Observational

Funder types: Other

Identifiers

NCT06946654

2025PHB131-001

Details and patient eligibility

About

This comprehensive, multidimensional evaluation assesses patient-related factors, disease-related factors, donor-related factors, and treatment-related factors. The study aims to identify potential risk factors influencing transplant outcomes in elderly patients and enhance the outcomes of allo-HSCT.

Full description

This comprehensive, multidimensional evaluation assesses patient-related factors (e.g., age, physical function, and comorbidity index), disease-related factors (e.g., primary diagnosis and blast count), donor-related factors (e.g., donor age, sex, ABO, and type), and treatment-related factors (e.g., conditioning regimen, graft source, and GVHD prophylaxis). The study aims to identify potential risk factors influencing transplant outcomes in elderly patients, establish a comprehensive geriatric assessment model, and guide personalized pre-transplant treatment strategies to reduce transplant-related mortality (TRM). Ultimately, we hope this study could help enhance the outcomes of allogenic hematopoietic stem cell transplantation (allo-HSCT).

Enrollment: 176 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• (a)Age ≥55 years.
• (b)Hematologic disorders with established indications for transplantation, including malignant and non-malignant hematologic diseases. (c)Willingness to provide informed consent.

Exclusion Criteria: (a)Pregnancy. (b) Uncontrolled active infection. (c) Lack of informed consent. (d)Deemed ineligible for transplantation after investigator assessment

Trial design

176 participants in 1 patient group

Geriatric Assessment

Treatment:

Procedure: Geriatric Assessment