Germ Cell Tumor and Testicular Tumor DNA Registry

Memorial Sloan Kettering Cancer Center (MSK)

Status: Enrolling

Conditions: Germ Cell Tumor; Testicular Tumor

Treatments: Behavioral: Questionnaires; Other: sample of blood or saliva

Study type: Observational

Funder types: Other

Identifiers

NCT02099734

14-016

Details and patient eligibility

About

This study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about the prevention, diagnosis, treatment and outcome of these tumors. Studying relatives of patients and people unrelated to patients with GCT and other testicular tumors will help us understand why some people get these tumors and why some people don't.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Case Cohort

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must have a diagnosis or suspicion of germ cell tumor and/or a testicular mass

Family Member Cohort

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband.

Control Cohort

• Must be ≥ 18 years of age AND
• Must be an English-speaker AND
• Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND
• Must not have a family history of germ cell tumor or testicular tumor AND
• Must not be a blood relative of controls enrolled in this study

Exclusion Criteria:

Trial design

1,000 participants in 3 patient groups

A: suspicion of germ cell tumor and/or a testicular mass

Description:

patients with testicular GCTs and non-GCT testicular tumors, extragonadal male GCTs, and female GCTs,

Treatment:

Other: sample of blood or saliva

Behavioral: Questionnaires

B: family members of Group A

Description:

relatives of patients with GCTs or testicular tumors

Treatment:

Other: sample of blood or saliva

Behavioral: Questionnaires

C: healthy controls unrelated to Group A or B

Description:

healthy controls who are unrelated to Groups A or B and do not have a personal history of cancer nor a family history of GCT or non-GCT testicular tumors

Treatment:

Other: sample of blood or saliva

Behavioral: Questionnaires