German Spondyloarthritis Inception Cohort (GESPIC)

Charité University Medicine Berlin

Status: Enrolling

Conditions: Acute Anterior Uveitis (AAU); Axial Psoriatic Arthritis (axPsA); Non-radiographic Axial Spondyloarthritis (Nr-axSpA); Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA); Ulcerative Colitis (UC); Crohn Disease (CD)

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01277419

GESPIC

Details and patient eligibility

About

The German Spondyloarthritis Inception cohort (GESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in Germany on patients with early SpA including ankylosing spondylitis (AS, also known as radiographic axial spondyloarthritis) and non-radiographic axial SpA. The objectives of GESPIC are to learn about the course of SpA during the very early stage of the disease, to appropriately assess the outcome including radiographic progression of patients after several years of follow-up, to identify outcome predictors, to assess quality of life, function, and costs (direct and indirect costs). GESPIC has been recently expanded to recruit patients with other forms of SpA / conditions associated with SpA: acute anterior uveitis, Crohn's disease as well as with psoriasis / axial psoriatic arthritis.

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Main inclusion Criteria:

• Patients with definite diagnosis of axial spondyloarthritis or juvenile spondyloarthritis.
• Patients with definite diagnosis of Crohn's disease.
• Patients with definite diagnosis of acute anterior uveitis.
• Patients with definite diagnosis of psoriatic arthritis with axial involvement.

Trial design

1,000 participants in 6 patient groups

Ankylosing spondylitis

Description:

Ankylosing spondylitis according to the modified New York criteria or with the clinical diagnosis of AS/r-axSpA fulfilling the ASAS Classification Criteria AND the mNY criteria plus having the indiaction for starting a bDMARD therapy according to the treating rheumatologist

Non-radiographic axial spondyloarthritis

Description:

Patients with clinical characteristics of axial SpA but not fulfilling the modified New York criteria for which radiographic sacroiliitis is essential or with the clinical diagnosis of nr-axSpA fulfilling the ASAS Classification Criteria not fulfilling the mNY criteria and the indiaction for starting a bDMARD therapy according to the treating rheumatologist

Juvenile spondyloarthritis

Description:

Patients with juvenile spondyloarthritis (juvenile ankylosing spondylitis, juvenile non-AS-spondyloarthritis).

Crohn's disease

Description:

Patients with Crohn's disease

Acute anterior uveitis

Description:

Patients with acute anterior uveitis

Axial psoriatic arthritis

Description:

Patients with the clinical diagnosis of psoriatic arthritis with axial involvement (sacroiliac joints and/or spine) (axPsA)