Gestational Diabetes Mellitus and Cardiovascular Disease: The Role of Vascular Dysfunction

Mass General Brigham

Status: Unknown

Conditions: Gestational Diabetes Mellitus; Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT00998712

2009P001255

Details and patient eligibility

About

The purpose of this research study is to look at whether there are differences in blood vessel function, risk for developing diabetes (high blood sugar), lipid (blood fat) levels, and levels of other blood markers between black women and white women who have or do not have gestational diabetes mellitus.

Enrollment: 88 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy women of self-identified African descent (black) and European (white) ancestry,
• 18-40 years of age,
• Body mass index < 35 kg/m2
• History of regular menstrual cycles,
• Are currently pregnant and in third trimester of pregnancy (after 24 weeks gestational age)
• Have no pregnancy-associated complications to-date
• Are in good health free of hypertension, as well as thyroid, cardiac, or renal disease.

Exclusion criteria

• History of smoking
• Are taking potentially vasoactive medications

Trial design

88 participants in 4 patient groups

1

Description:

Black women in the third trimester of a pregnancy complicated by gestational diabetes.

2

Description:

Black women in the third trimester of a normal, uncomplicated pregnancy.

3

Description:

White women in the third trimester of a pregnancy complicated by gestational diabetes.

4

Description:

White women in the third trimester of a normal, uncomplicated pregnancy.