Ghrelin Changes After Roux-en-Y Gastric Bypass

Vanderbilt University

Status: Completed

Conditions: Insulin Resistance; Obesity

Treatments: Other: Liquid diet for 3 days

Study type: Observational

Funder types: Other

Identifiers

NCT00765596

IRB#041129

Details and patient eligibility

About

The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects.

Enrollment: 14 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Serum creatinine and liver function tests < upper limits of normal
• Stable body weights for the past three months
• Women will have a negative pregnancy test
• patients who are already scheduled for RYGB with gastrostomy tube placement

Exclusion criteria

• Significant hepatic enzyme elevations (more than 100% of upper limits of normal)
• Serum creatinine > 1.5 mg/dl
• history of ketoacidosis or current metabolic acidosis
• current use of oral anticoagulants
• Positive pregnancy test (beta-human chorionic gonadotrophin) for females
• intercurrent infections
• patients with prior gastric operations

Trial design

14 participants in 2 patient groups

1 RYGB

Description:

Subjects undergoing RYGB with gastric tube placement

2 Matched controls

Description:

Subjects matched by BMI, age, gender to RYGB group

Treatment:

Other: Liquid diet for 3 days