Ghrelin Decreases Insulin Sensitivity

University of Aarhus

Status and phase: Completed; Phase 1

Conditions: Healthy Subjects

Treatments: Drug: Ghrelin and saline (as placebo)

Study type: Interventional

Funder types: Other

Identifiers

NCT00512525

ETV2007

Details and patient eligibility

About

Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.

Full description

The current study is initiated in order to assess the impact of acute ghrelin administration on insulin resistance measured by a hyperinsulinemic euglycemic clamp. Second, as free fatty acid is the predominant substrate during fasting, we aim to asses the effects of ghrelin on local and systemic lipolysis.

Enrollment: 8 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men, age >= 18 yr age < 50 yr, body mass index < 27.5 kg/m2above or equal to 18 yr

Exclusion criteria

• any disease, use of prescribed medication, age < 18 yr or >= 50 yr

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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8 participants in 1 patient group, including a placebo group

2

Placebo Comparator group

Treatment:

Drug: Ghrelin and saline (as placebo)