Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients

University of Aarhus

Status: Completed

Conditions: Hypopituitarism

Treatments: Drug: Human acylated ghrelin

Study type: Interventional

Funder types: Other

Identifiers

NCT00139945

2004/102

Details and patient eligibility

About

In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.

Enrollment: 8 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 60 yrs.
• Verified hypopituitarism
• Unchanged substitution treatment through 3+ months
• Unchanged additional medical treatment
• Oral and written informed consent

Exclusion criteria

• Age below 18 or above 60 yrs.
• Diabetes mellitus
• body mass index > 30
• Fasting hypoglycemia
• Convulsions
• Allergy to trial products

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind