Ghrelin Levels in Patients With Protein C Deficiency
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About
In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients.
30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite.
If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.
Enrollment
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Inclusion criteria
- protein C deficiency or healthy subjects
- age 18-70
- BMI 18-35
- written statement to join the study
Exclusion criteria
- chronic illness, apart from protein C deficiency and lifestyle diseases
- everyday medication apart from statins, oral diabetes medication and antihypertensive drugs.
- blood donation within three months prior to the investigation.
- Alcohol abuse
Trial design
60 participants in 2 patient groups
Trial contacts and locations
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Central trial contact
Rakel F Johansen, MD; Sascha S Horup, MD
Data sourced from clinicaltrials.gov
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