Ginger Capsules for the Prophylactic Treatment of Migraine

Federal University of Minas Gerais

Status: Completed

Conditions: Migraine

Treatments: Other: Cellulose; Other: Extract of ginger

Study type: Interventional

Funder types: Other

Identifiers

NCT02570633

CAAE 28236814.3.0000.5149

Details and patient eligibility

About

The main objective of the study is to evaluate ginger efficacy as an prophylactic treatment of migraine.

Full description

Patients with the diagnosis of migraine according to the IHS criteria will receive capsules of 200 mg of ginger extract (5% active ingredient) or placebo (cellulose) to be taken three times a day for 12 weeks.

Enrollment: 107 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 18 and 60 years old;
• Migraine diagnosis;
• Agree to sign the informed consent.

Exclusion criteria

• Patients with headaches not characterized as migraine;
• Pregnant or lactating women;
• Fertile and sexually active women who do not use contraception;
• Abuse of painkillers, alcohol or other drugs;
• People with hypersensitivity to ginger compounds;
• People with severe neurological diseases (e.g. epilepsy)
• People in use of anticoagulant drugs.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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107 participants in 2 patient groups, including a placebo group

Extract of ginger

Experimental group

Description:

Migraine patients (both genders) will receive capsules of 200 mg of ginger extract (5% gingerols) to be taken three times a day for 12 weeks.

Treatment:

Other: Extract of ginger

Cellulose

Placebo Comparator group

Description:

Migraine patients (both genders) will receive capsules of 200 mg of placebo (cellulose) to be taken three times a day for 12 weeks.

Treatment:

Other: Cellulose