Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy (GINGER-PONV)

University Tunis El Manar

Status and phase: Enrolling; Phase 4

Conditions: Laparoscopic Cholecystectomy; Postoperative Nausea and Vomiting

Treatments: Drug: Ginger; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT07190495

GINGER PONV

Details and patient eligibility

About

This study aims to evaluate whether preoperative oral administration of ginger (800 mg, given 2 hours before surgery) reduces the incidence and severity of postoperative nausea and vomiting (PONV) within the first 24 hours after laparoscopic cholecystectomy.

Enrollment: 102 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years.
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
• American Society of Anesthesiologists (ASA) physical status I-III.
• Able to understand the study procedures and provide written informed consent.

Exclusion criteria

• Known allergy or hypersensitivity to ginger
• Documented history of bleeding disorders or current treatment with anticoagulant agents
• History of severe postoperative nausea and vomiting or an Apfel score of 4
• Administration of antiemetic drugs or corticosteroids during the preoperative period
• Pregnancy or breastfeeding
• Active gastrointestinal or liver disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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102 participants in 2 patient groups, including a placebo group

Ginger group

Active Comparator group

Description:

Patients will receive 800 mg of oral ginger 2 hours before laparoscopic cholecystectomy

Treatment:

Drug: Ginger

Placebo group

Placebo Comparator group

Description:

Patients will receive an oral placebo capsule identical in appearance to ginger, administered 2 hours before laparoscopic cholecystectomy

Treatment:

Drug: Placebo