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Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

A

Ain Shams University

Status

Completed

Conditions

Chronic Periodontitis
Preterm Labor

Study type

Observational

Funder types

Other

Identifiers

NCT03171675
22/01/2014 #33;

Details and patient eligibility

About

This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.

Enrollment

40 patients

Sex

Female

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Within the age range of 18-35 years
  2. Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008)
  3. Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications
  4. Spontaneous preterm birth (PTB) at <37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999)

Exclusion criteria

  1. History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month
  2. Genital and urinary tract infections
  3. Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease
  4. Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage
  5. Low or high maternal body mass index

Trial design

40 participants in 4 patient groups

Preterm/Chronic Periodontitis
Description:
Included ten female patients who underwent spontaneous preterm birth and were diagnosed with chronic periodontitis upon clinical examination
Preterm/Healthy Periodontium
Description:
Included ten female patients who underwent spontaneous preterm birth and who had a healthy periodontium upon clinical examination
Term/Chronic Periodontitis
Description:
Included ten female patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination
Term/Healthy Periodontium
Description:
Included ten female patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (Armitage1999)

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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