Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

Ain Shams University

Status: Completed

Conditions: Chronic Periodontitis; Preterm Labor

Study type: Observational

Funder types: Other

Identifiers

NCT03171675

22/01/2014 #33;

Details and patient eligibility

About

This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Within the age range of 18-35 years
2. Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008)
3. Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications
4. Spontaneous preterm birth (PTB) at <37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999)

Exclusion criteria

1. History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month
2. Genital and urinary tract infections
3. Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease
4. Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage
5. Low or high maternal body mass index

Trial design

40 participants in 4 patient groups

Preterm/Chronic Periodontitis

Description:

Included ten female patients who underwent spontaneous preterm birth and were diagnosed with chronic periodontitis upon clinical examination

Preterm/Healthy Periodontium

Description:

Included ten female patients who underwent spontaneous preterm birth and who had a healthy periodontium upon clinical examination

Term/Chronic Periodontitis

Description:

Included ten female patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination

Term/Healthy Periodontium

Description:

Included ten female patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (Armitage1999)