Gingival Crevicular Fluid of Adiponectin and Resistin As Predictable Implement in Staging and Grading System of Periodontitis

Al-Azhar University

Status: Completed

Conditions: Periodontal Diseases; Obesity, Morbid

Treatments: Procedure: non-surgical full-mouth periodontal therapy without using adjunct disinfectants; Diagnostic Test: GCF level of adiponectin and resistin

Study type: Interventional

Funder types: Other

Identifiers

NCT06604013

Obesity and Periodontitis

Details and patient eligibility

About

The goal of this clinical trial is to evaluate the relationship between obesity and gingival crevicular fluid resistin and adiponectin in periodontitis patients as well as assess the effect of non-surgical periodontal therapy on their levels using ELISA in obese individuals. Researchers will compare different stages of periodontitis to see if degrees of inflammation and periodontal therapy related obesity

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obese persons with Body Mass Index (BMI) more than 40 and suffering from periodontitis

Exclusion criteria

• Patients receiving either antibiotics or non-steroidal anti- inflammatory at least 3 months prior to samples collection.
• Patients subjected to previous periodontal therapy 6 months before sampling. Patients with systemic or local inflammatory conditions other than periodontal disease.
• Neither lactating nor pregnant.

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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60 participants in 4 patient groups

mild periodontitis (first stage, grade B)

Active Comparator group

Description:

mild periodontitis (first stage, grade B) manifesting CAL ≥ 1-2 mm, in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants.

Treatment:

Diagnostic Test: GCF level of adiponectin and resistin

Procedure: non-surgical full-mouth periodontal therapy without using adjunct disinfectants

moderate periodontitis (second stage, grade B)

Active Comparator group

Description:

moderate periodontitis (second stage, grade B) manifesting CAL ≥ 3-4mm in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants.

Treatment:

Diagnostic Test: GCF level of adiponectin and resistin

Procedure: non-surgical full-mouth periodontal therapy without using adjunct disinfectants

severe periodontitis (third stage, grade B)

Active Comparator group

Description:

severe periodontitis (third stage, grade B) manifesting CAL ≥ 5mm , in corporation with BoP increased than (30%), percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants

Treatment:

Diagnostic Test: GCF level of adiponectin and resistin

Procedure: non-surgical full-mouth periodontal therapy without using adjunct disinfectants

very severe periodontitis (forth stage, grade C)

Active Comparator group

Description:

very severe periodontitis (forth stage, grade C) manifesting CAL ≥ 5mm in corporation of percentage of bone loss level divided by age more than 1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants

Treatment:

Diagnostic Test: GCF level of adiponectin and resistin

Procedure: non-surgical full-mouth periodontal therapy without using adjunct disinfectants