Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes

Uşak University

Status: Completed

Conditions: Periodontitis; Diabetes

Treatments: Diagnostic Test: Gingival crevicular fluid

Study type: Observational

Funder types: Other

Identifiers

NCT04891627

UsakU8

Details and patient eligibility

About

Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim of this study to investigate GCF levels of IL-34 and CSF-1 in periodontitis subjects with diabetes.

Full description

Periodontally healthy (H), periodontitis, and periodontitis with diabetes patients, were recruited for this study.

1. Inclusion criteria for H groups: Individuals with clinically healthy gingiva, no attachment and bone loss, and less than 10% bleeding on probing were included.
2. Inclusion criteria for periodontitis groups: Systemically healthy individuals with interdental CAL ≥ 5 mm and PPD ≥ 6 mm were included.
3. Inclusion criteria for periodontitis with diabetes groups: Type 2 diabetes patients with interdental CAL ≥ 5 mm, PPD ≥ 6 mm, and HbA1c ≥ 6.5% were included.

The plaque index (PI), gingival index (GI), presence of bleeding on probing (BOP), PD, and clinical AL were used for clinical periodontal assessments. All assessments were done with a manual probe. GCF samples were obtained and analyzed using an enzyme-linked immunosorbent assay.

Enrollment: 76 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• have 20 teeth
• have diabetes .

Exclusion criteria

• Individuals have systemic disease
• smokers;
• pregnant
• those using drugs;

Trial design

76 participants in 3 patient groups

Healthy control groups

Description:

individuals with clinically healthy gingiva BOP score less than 10% and PD≤3mm

Treatment:

Diagnostic Test: Gingival crevicular fluid

Periodontitis group

Description:

interdental AL ≥5 mm

Treatment:

Diagnostic Test: Gingival crevicular fluid

Periodontitis with diabetes group

Description:

HbA1c ≥6.5%

Treatment:

Diagnostic Test: Gingival crevicular fluid