Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity

Sunway University

Status and phase: Completed; Early Phase 1

Conditions: Cognition; Blood Pressure

Treatments: Drug: Placebo; Drug: Ginseng; Drug: Ginkgo Biloba

Study type: Interventional

Funder types: Other

Identifiers

NCT02386852

Sunway-979

Details and patient eligibility

About

There is some evidence to suggest that ginseng and Ginkgo biloba can improve cognitive performance, however, very little is known about the mechanisms associated with such improvement. Here, we tested whether cardiovascular reactivity to a task is associated with cognitive improvement.

Enrollment: 48 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers ranging in age between 18 and 30.

Exclusion criteria

• Ginseng group: exclude those that regularly consume caffeine or Panax Ginseng, or those that are diabetic, have hormone sensitive conditions, autoimmune diseases, bleeding conditions, heart conditions or take medications that are known to interact with Panax Ginseng. These include anticoagulants, Warfarin, Ibuprofen, MAOIs, medications that are changed by the liver, and stimulant drugs (e.g. pseudoephedrine, epinephrine).
• Ginkgo Biloba group: exclude those that regularly consume caffeine or Ginkgo Biloba, or those that are diabetic, have experienced seizures in the past, have bleeding disorders, or take medications that are known to interact with Ginkgo Biloba. These include Ibuprofen, anticoagulants, Warfarin, Buspirone, Fluoxetine, Trazodone

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

48 participants in 3 patient groups

Placebo

Experimental group

Description:

Study subjects received, in a double blind fashion, placebo pills identical to the drug (ginseng: group 1; ginkgo biloba: group 2).

Treatment:

Drug: Ginseng

Drug: Placebo

Drug: Ginkgo Biloba

Ginseng

Experimental group

Description:

Participants in the ginseng group received a medium, and higher dose of ginseng in addition to placebo capsules.

Treatment:

Drug: Ginseng

Drug: Placebo

Ginkgo Biloba

Experimental group

Description:

Participants in the ginkgo biloba group received a medium, and higher dose of ginkgo in addition to placebo capsules.

Treatment:

Drug: Placebo

Drug: Ginkgo Biloba