ClinicalTrials.Veeva

Menu

GIP Receptor Antagonist Studies in Humans (GA-1)

U

University Hospital, Gentofte, Copenhagen

Status

Completed

Conditions

Glucose Metabolism

Treatments

Drug: GIP-A
Drug: GIP(1-42)
Other: Saline

Study type

Interventional

Funder types

Other

Identifiers

NCT02747472
UHG-CFD-GIPANTA-1

Details and patient eligibility

About

Antagonizing GIP effects during hyperglycaemia in healthy subjects and measurements of insulin secretion.

Full description

Aim: To evaluate the GIP receptor antagonizing effect of peptide-based competitive GIP receptor antagonist GIP-A (vs. saline (placebo)) in 10 healthy subjects during 1 hour hyperglycaemic clamps with and without concomitant iv infusion of GIP[1-42]. The intention is to establish GIP-A as a tool to eliminate glucose-dependent insulinotropic GIP signalling.

The study consists of four experimental days (A-D) with assessment of beta cell function during 12 mM-hyperglycaemic clamps with concomitant infusions of A) GIP[1-42], B) GIP-A, C) GIP[1-42] + GIP-A, or D) saline (placebo).

Enrollment

10 patients

Sex

Male

Ages

20 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Normal kidney function, liver function and hemoglobin levels.

Exclusion criteria

  • Medication, Diabetes type 1 or 2, BMI > 25, first degree relatives with Type 2 Diabetes

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

10 participants in 4 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
Infusion of saline
Treatment:
Other: Saline
GIP(1-42)
Active Comparator group
Description:
Infusion of agonist, GIP(1-42)
Treatment:
Drug: GIP(1-42)
GIP-A
Experimental group
Description:
Infusion of GIP-A alone
Treatment:
Drug: GIP-A
GIP-A + GIP(1-42)
Experimental group
Description:
Infusion of GIP-A and GIP(1-42)
Treatment:
Drug: GIP-A
Drug: GIP(1-42)

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems