Glasgow Coma Scales and General Anesthesia

Trakya University

Status: Completed

Conditions: Anesthesia Awareness

Treatments: Drug: Sevoflurane; Device: Bispectral index (BIS) monitoring

Study type: Interventional

Funder types: Other

Identifiers

NCT03521414

TÜTF-GOKAEK 2013/127

Details and patient eligibility

About

The study evaluates the general anesthesia management with BIS monitorization in terms of hemodynamic stability, drug concentrations and drug consumption in patients who underwent surgery due to intracranial pathology and who were divided in three different GCS groups.

Full description

BIS monitoring is mostly used for anesthesia depth and sedation level follow-up, however it can also be used for monitoring consciousness after resuscitation of cases with acute brain injury and cardiac arrest. It is not always possible to monitor and objectively measure the changes in the level of consciousness in clinical practice. Therefore, device-based methods have been introduced in monitoring the state of consciousness. Bispectral index (BIS) monitoring may be preferred in follow up of the state of consciousness in critical patients such as those with acute brain injury, in terms of ease of use, ability to obtain numerical results and continuous monitoring. BIS monitoring is mostly used for follow up of anesthesia depth and sedation level, while it can also be applied for monitoring state of consciousness following resuscitation in cases with acute brain injury and cardiac arrest.In this study, we aimed to investigate general anesthesia management performed by bispectral index monitoring in patients who underwent surgery due to intracranial pathology and with different Glasgow Coma Scales.

Enrollment: 45 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 and 65 years
• ASA II-III
• intracranial surgery

Exclusion criteria

• Patients with additional disease (electrolyte impairment, uremia, etc.),
• liver and renal failure affecting consciousness level other than intracranial pathology

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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45 participants in 3 patient groups

Group I=13-15 mildly injured

Active Comparator group

Description:

Patients were divided into 3 groups according to the Glasgow Coma Scores calculated before surgery. use of anesthetic agent were recorded during bispectral index (BIS) monitoring and anesthesia application. we used sevoflurane drug intraoperative. Group I (n=15)=13-15 mildly injured

Treatment:

Device: Bispectral index (BIS) monitoring

Drug: Sevoflurane

Group 2 =9-12 moderately damaged

Active Comparator group

Description:

Patients were divided into 3 groups according to the Glasgow Coma Scores calculated before surgery.use of anesthetic agent were recorded during bispectral index (BIS) monitoring and anesthesia application. we used sevoflurane drug intraoperative. Group 2 (n=15)=9-12 moderately damaged

Treatment:

Device: Bispectral index (BIS) monitoring

Drug: Sevoflurane

Group 3=3-8 severely damaged.

Active Comparator group

Description:

Patients were divided into 3 groups according to the Glasgow Coma Scores calculated before surgery. use of anesthetic agent were recorded during bispectral index (BIS) monitoring and anesthesia application. we used sevoflurane drug intraoperative. Group 3 (n=15)=3-8 severely damaged.

Treatment:

Device: Bispectral index (BIS) monitoring

Drug: Sevoflurane