Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project (GRACefUl)

Istituto Ortopedico Rizzoli

Status: Enrolling

Conditions: Undifferentiated Round Cell Sarcoma

Treatments: Other: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue

Study type: Observational

Funder types: Other

Identifiers

NCT05357768

GRACefUl

Details and patient eligibility

About

Experimental study with biological material : case series review of clinical and histological data

Full description

This is a multicenter retrospective and prospective study that will analyze all cases with a diagnosis of Undifferentiated round cell sarcomas from 01 January 1983 and all new cases referring to each participant site.

Enrollment: 260 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included.
• Clinical and outcome information available.
• Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available.

Exclusion criteria

• Diagnosis different from undifferentiated round cell sarcomas
• Patient with no clinical or outcome information available

Trial design

260 participants in 2 patient groups

retrospective cohort

Description:

Patients with undifferentiated round cell sarcomas treated from 01 January 1983 to April 2019 will be included. For retrospective analysis, it is expected to include about 200 patients.

Treatment:

Other: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue

prospective cohort

Description:

prospective patients with undifferentiated round cell sarcomas will be included in the study. For prospective study, it is expect to include 60 patients.

Treatment:

Other: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue