Global Syphilis Sequencing

London School of Hygiene and Tropical Medicine

Status: Completed

Conditions: Syphilis

Treatments: Diagnostic Test: Whole Genome Sequencing

Study type: Observational

Funder types: Other

Identifiers

NCT03709862

16014

Details and patient eligibility

About

Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches allow the whole genetic sequence of Treponema pallidum to be obtained from a swab.

In this study residual DNA collected as part of routine patient care of patients seen at sexual health clinics in the UK will be used for sequencing. No patient contact is involved in the study which is limited to whole genome sequencing using residual material from samples. By better understanding the genome of the T.pallidum insights will be gained in to the pathogenesis of this important sexually transmitted disease.

Enrollment: 726 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of syphilis

Exclusion criteria

• No PCR positive clinical sample

Trial design

726 participants in 1 patient group

Syphilis

Description:

Patients with syphilis and detectable Treponema pallidum DNA in a routinely collected clinical sample

Treatment:

Diagnostic Test: Whole Genome Sequencing