GLP-1 Response in Women With PCOS and Prediabetes

University Medical Centre Ljubljana

Status: Completed

Conditions: Incretin Hormones in PCOS With Prediabetes

Treatments: Diagnostic Test: oral glucose tolerance test

Study type: Interventional

Funder types: Other

Identifiers

NCT03325569

IGH PCOS and inkretins

Details and patient eligibility

About

Women with PCOS are more prone to obesity which exacerbates insulin resistance, the abdominal fat disposition and metabolic risk of these patients. With development of obesity these women have high conversion rate from normal glucose tolerance to impaired glucose tolerance and in turn to type 2 diabetes.

Glucagon-like peptide 1 (GLP-1) is involved in body weight maintenance. Beside energy balance it is also involved in glucose homeostasis. Functional deficit in GLP-1 facilitates obesity. We investigated the link between the concentration of incretin hormones and glucose homeostasis, metabolic complications and the distribution of body composition in obese women with PCOS.

Enrollment: 26 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years old to menopause
• polycystic ovary sindrome (NICHD criteria)
• BMI of 30 kg/m2 or higher

Exclusion criteria

• type 1 or type 2 diabetes mellitus
• Cushing's syndrome or congenital (non-classic) adrenal hyperplasia
• personal or family history of MEN 2
• the use of medications known or suspected to affect reproductive or metabolic functions
• the use of statins within 90 days prior to study entery

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

NGT

Active Comparator group

Description:

NGT - normal glucose tolerance. Women with PCOS and normal glucose tolerance

Treatment:

Diagnostic Test: oral glucose tolerance test

IGH

Active Comparator group

Description:

IGH - impaired glucose homeostasis Women with PCOS and impaired glucose homeostasis - that means impaired fasting glucose or impaired glucose tolerance.

Treatment:

Diagnostic Test: oral glucose tolerance test