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GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow

Z

Zealand University Hospital

Status

Unknown

Conditions

Healthy

Treatments

Other: Exendin-4 ;10 ug,sc injection
Other: saline
Other: 1,5 nmol/kg GLP-1 9-36amide, sc injection
Other: 1,5 nmol/kg,GLP-1 sc injection

Study type

Interventional

Funder types

Other

Identifiers

NCT01988545
2013.GLP-1

Details and patient eligibility

About

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters

Full description

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters, in healthy subjects, 4 arms, task force monitor

Enrollment

8 estimated patients

Sex

All

Ages

20 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy subjects

Exclusion criteria

  • medical conditions

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

Double Blind

8 participants in 4 patient groups, including a placebo group

GLP-1
Active Comparator group
Description:
1,5 nmol/kg,GLP-1 sc injection
Treatment:
Other: Exendin-4 ;10 ug,sc injection
Other: 1,5 nmol/kg GLP-1 9-36amide, sc injection
GLP-1 9-36amide
Active Comparator group
Description:
1,5 nmol/kg GLP-1 9-36amide, sc injection
Treatment:
Other: Exendin-4 ;10 ug,sc injection
Other: 1,5 nmol/kg,GLP-1 sc injection
Exendin-4
Active Comparator group
Description:
Exendin-4 ;10 ug,sc injection
Treatment:
Other: 1,5 nmol/kg,GLP-1 sc injection
Other: 1,5 nmol/kg GLP-1 9-36amide, sc injection
isotonic saline
Placebo Comparator group
Description:
2 ml of isotonic saline, sc injection
Treatment:
Other: 1,5 nmol/kg,GLP-1 sc injection
Other: saline
Other: 1,5 nmol/kg GLP-1 9-36amide, sc injection

Trial contacts and locations

1

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Central trial contact

Lasse Bremholm, MD, ph.d.

Data sourced from clinicaltrials.gov

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