Glu298Asp Polymorphism and Blood Pressure

University of Reading

Status: Completed

Conditions: Hypertension

Treatments: Dietary Supplement: Bread

Study type: Interventional

Funder types: Other

Identifiers

NCT02037308

University of Reading (Other Identifier)

10/18G

Details and patient eligibility

About

The Glu298Asp polymorphism has been linked to increased risk of cardiovascular events, proposed to be due to reduced nitric oxide production by eNOS reported in some but not all studies. We hypothesise that beetroot-enriched bread interacts with the Glu298Asp polymorphism of the eNOS gene to lower blood pressure and increase plasma nitrate/nitrite, particularly in carriers of the T allele, which have been associated with lower eNOS activity and increased risk of hypertension.

Enrollment: 14 patients

Sex: Male

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• A signed consent form
• Age 18-64 years
• Body mass index - 18.5-30 kg/m2
• Non-smoking, healthy individuals
• Normal blood pressure at screening (< 150/90)

Exclusion criteria

• Subjects with anaemia
• Sufferers of chronic illnesses
• Individuals with food allergies
• People with diabetes
• People with coeliac disease
• Women
• Vegetarians

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 2 patient groups, including a placebo group

Control white bread

Placebo Comparator group

Treatment:

Dietary Supplement: Bread

Beetroot bread

Experimental group

Treatment:

Dietary Supplement: Bread