Glucocorticoids and Pulmonary Hypertension

The Washington University

Status: Unknown

Conditions: Pulmonary Hypertension Due to Lung Diseases and Hypoxia; Bronchopulmonary Dysplasia; Pulmonary Hypertension

Treatments: Drug: GlucoCorticoid

Study type: Observational

Funder types: Other

Identifiers

NCT04499196

LD2020

Details and patient eligibility

About

Pediatric idiopathic pulmonary hypertension has significant morbidity and mortality. An ever expanding body of knowledge indicates the important contribution of inflammation to pathogenesis and successful treatment with glucocorticoids. Over the last several years the investigators have utilized steroids in patients with severe pulmonary hypertension as part of a treatment regimen. These basic science studies possibly identifies a biochemical etiology for the development of disease and may also be impacted by the administration of steroids. Additionally, there is a commercially available assay which tests for all of the above molecules.

Enrollment: 40 estimated patients

Sex: All

Ages: 1 day to 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• premature, BPD, >36 wga
• pulmonary hypertension evidence by echocardiogram

Exclusion criteria

• poor ventilation/oxygenation