Glucosamine Sulfate Bioavailability

Isura

Status: Completed

Conditions: Bioavailability and Pharmacokinetics

Treatments: Dietary Supplement: Regular glucosamine sulfate; Dietary Supplement: Crystalline glucosamine sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT06971484

2022-11-002GS

Details and patient eligibility

About

This study aims to compare the pharmacokinetics and bioavailability of crystalline glucosamine sulfate and regular glucosamine sulfate using a double-blind, randomized, crossover design.

Enrollment: 10 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female aged 21- 65 years
• Healthy, good physical condition
• Voluntary, written, informed consent to participate in the study.

Exclusion criteria

• Serious acute or chronic diseases e.g. liver, kidney, or gastrointestinal diseases
• Use of medications affecting glucosamine metabolism
• Known allergies to shellfish or glucosamine
• Pregnancy or breastfeeding
• Participation in another investigational study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 2 patient groups

Crystalline glucosamine sulfate

Experimental group

Description:

Participants receive their treatment of crystalline glucosamine sulfate at a total dose of 1500 mg of glucosamine sulfate. Treatments are consumed with a glass of water followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 24 hours post-dose. A washout period of 1 week between each treatment is used.

Treatment:

Dietary Supplement: Crystalline glucosamine sulfate

Regular glucosamine sulfate

Experimental group

Description:

Participants receive their treatment of regular glucosamine sulfate at a total dose of 1500 mg of glucosamine sulfate. Treatments are consumed with a glass of water followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 24 hours post-dose. A washout period of 1 week between each treatment is used.

Treatment:

Dietary Supplement: Regular glucosamine sulfate