Glucose Absorption and Gut Hormone Secretion After Gastric Bypass

Hvidovre University Hospital

Status: Unknown

Conditions: Overweight

Treatments: Dietary Supplement: Glucose + Canagliflozin; Dietary Supplement: Glucose

Study type: Interventional

Funder types: Other

Identifiers

NCT03426956

CM-CANA-18

Details and patient eligibility

About

To investigate the impact of canagliflozin on secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1) in gastric bypass operated patients.

Full description

Glucose is a potent stimulus for GLP-1 secretion after gastric bypass surgery and the SGLT-1 transporter appears to be crucial for this response. The study will investigate the effects of SGLT-1/SGLT-2 inhibition (by canagliflozin) on secretion of GLP-1 and other gut hormones after gastric bypass surgery.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

•Uncomplicated gastric bypass surgery performed minimum 12 months prior to study

Exclusion criteria

• Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups

Glucose

Experimental group

Treatment:

Dietary Supplement: Glucose

Glucose + Canagliflozin

Experimental group

Treatment:

Dietary Supplement: Glucose + Canagliflozin