Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

University Hospital Basel

Status: Completed

Conditions: Exploratory Behavior

Treatments: Dietary Supplement: Tap water; Dietary Supplement: Glucose; Dietary Supplement: Fructose

Study type: Interventional

Funder types: Other

Identifiers

NCT02902224

fMRI BARI

Details and patient eligibility

About

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Enrollment: 15 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• right-handed
• morbidly obese patients
• scheduled for bariatric surgery

Exclusion criteria

• Diabetes mellitus
• cardiovascular disease
• neurologic or psychiatric disorder

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

---

15 participants in 3 patient groups, including a placebo group

PLACEBO

Placebo Comparator group

Description:

Single intragastric instillation of 300ml tap water via nasogastric tube

Treatment:

Dietary Supplement: Tap water

GLUCOSE

Active Comparator group

Description:

Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

Treatment:

Dietary Supplement: Glucose

FRUCTOSE

Active Comparator group

Description:

Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube

Treatment:

Dietary Supplement: Fructose