Glucose as a Mediator of Self-control Performances in Patients With Schizophrenia

The University of Hong Kong (HKU)

Status: Unknown

Conditions: Schizophrenia

Treatments: Dietary Supplement: glucose drink

Study type: Interventional

Funder types: Other

Identifiers

NCT01563016

selfcontrolvsglucose

Details and patient eligibility

About

The research aims to investigate the relationship between self-control ability and blood glucose level in schizophrenic patients. The main purpose of the present study is to explore whether the close relationship of blood glucose and self-regulatory strength observed in healthy individuals, is applicable to schizophrenic patients. More specifically, the current study aims

• to investigate whether the exertion of self-control reduces blood glucose,
• to examine whether low level of blood glucose deteriorates subsequent self-control performances
• to examine whether restoring the glucose level eliminates these impairments, in schizophrenic patients.

Enrollment: 100 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 15 or above
• DSM-IV diagnosis of schizophrenia, schizoaffective disorder, schizophreniform psychosis, brief psychosis, psychosis NOS or delusional disorder
• Cantonese-speaking Chinese
• Ability to understand the nature of the study and sign informed consent

Exclusion criteria

• Organic Brain disorder
• Known history of intellectual disability
• Priority Follow Up (Subtarget or Target)
• All allergic to any sugar or artificial sweeteners
• Diabetics
• Physical Disability

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 4 patient groups, including a placebo group

Glucose & Depleting

Experimental group

Description:

participants will perform in a depleting task and receive a glucose drink

Treatment:

Dietary Supplement: glucose drink

Glucose & non-depleting

Placebo Comparator group

Description:

participants will perform in a non-depleting task and receive a glucose drink

Treatment:

Dietary Supplement: glucose drink

Placebo & depleting

No Intervention group

Description:

participants will perform in a depleting task and receive a placebo drink

Placebo & non depleting

No Intervention group

Description:

participants will perform in a non depleting task and receive a placebo drink