Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

Hvidovre University Hospital

Status: Completed

Conditions: Healthy Subjects

Treatments: Other: Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)

Study type: Observational

Funder types: Other

Identifiers

NCT00999271

HD-2009-0025

Details and patient eligibility

About

The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Informed oral and written consent
• Caucasians over the age of 18 years
• Normal 75 g oral glucose tolerance test (OGTT)
• Normal blood haemoglobin concentration
• Normal plasma lipid profile

Exclusion criteria

• First-degree relatives with diabetes and familial hypertriglyceridemia

Trial design

30 participants in 1 patient group

Healthy subjects

Description:

30 healthy subjects without family history of diabetes or gastrointestinal disease, a normal oral glucose tolerance test (OGTT) and no intake of medicine

Treatment:

Other: Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)