Glucose-fructose Ratio Pilot

University of Bath

Status: Enrolling

Conditions: Exercise Metabolism

Treatments: Other: Glucose and fructose (one-to-one); Other: Glucose and fructose (two-to-one)

Study type: Interventional

Funder types: Other

Identifiers

NCT07360249

11030 (Registry Identifier)

Details and patient eligibility

About

The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 18 years and above;
• Performing endurance training for at least 5 hours per week
• Capable of three hours of continuous exercise

Exclusion criteria

• Glucose or lipid lowering, or weight loss medication
• Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
• Contraindications to exercise
• Pregnant or lactating

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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10 participants in 2 patient groups

One to One ratio

Experimental group

Description:

Glucose and fructose ingestion in a one-to-one ratio

Treatment:

Other: Glucose and fructose (one-to-one)

Two to one ratio

Active Comparator group

Description:

Glucose and fructose ingestion in a two-to-one (1-to-0.5) ratio

Treatment:

Other: Glucose and fructose (two-to-one)