Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.

The University of Chicago

Status: Completed

Conditions: Insulin Resistance; Type 2 Diabetes; Sleep

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00720889

R01HL089637 (U.S. NIH Grant/Contract)

16079A-S2

Details and patient eligibility

About

The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

Full description

On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Enrollment: 20 patients

Sex: All

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• regular sleep habits
• BMI 20 to 27 kg/m2
• at least one parent, sibling or grandparent with type 2 diabetes
• no regular exercise habits

Exclusion criteria

• active smoker
• night or shift work
• have highly variable sleep habits
• have a hormonal disorder
• have a sleep disorder
• have an active medical problem
• women only: use of birth control pills
• women only: irregular menstrual periods or pregnancy
• use of medications/compounds that can disrupt sleep

Trial design

20 participants in 2 patient groups

Reduced sleep

Description:

Habitual sleep duration of less than 6 hours per night on most days of the week and total sleep of less than 43 hours per week.

Reference sleep

Description:

Habitual sleep duration between 7 and 8.5 hours per night on most days of the week and total sleep of at least 53 hours per week.